prevention of nonalcoholic steatohepatitis in rats by two manganese-salen complexes
نویسندگان
چکیده
background: nonalcoholic steatohepatitis (nash), a progressive stage of nonalcoholic fatty liver disease (nafld), is characterized by steatosis with inflammation. investigations have suggested that oxidative stress may play an important role in the progress of nafld to nash. to provide further insights into beneficial effects of antioxidants in nash prevention, we employed two manganese-superoxide dismutase/catalase mimetics, manganese n,n`-bis(salicyldene) ethylene diamine chloride (euk-8) and manganese-3-methoxy n,n`-bis(salicyldene)ethylenediamine chloride (euk-134), as two salen representatives and vitamin c as the standard antioxidant. methods: experimental nash was induced in male n-mary rats by feeding a methionine/choline-deficient (mcd) diet to rats for 10 weeks. the rats (n = 5, 30 mg/kg/day) were randomly assigned to receive vitamin c, euk-8, euk-134 or vehicle orally. results: administration of salens together with the mcd diet reduced the serum aminotransferases, glutathione transferase and alkaline phosphatase, cholesterol, and ldl contents. in addition, the euk-8 and euk-134 improved nash pathological features in liver of mcd-fed rats. conclusion: euk-8 and euk-134 supplementation reduces nash-induced abnormalities, pointing out that antioxidant strategy could be beneficial for prevention of nash.
منابع مشابه
Prevention of Nonalcoholic Steatohepatitis in Rats by Two Manganese-Salen Complexes
Background: Nonalcoholic steatohepatitis (NASH), a progressive stage of nonalcoholic fatty liver disease (NAFLD), is characterized by steatosis with inflammation. Investigations have suggested that oxidative stress may play an important role in the progress of NAFLD to NASH. To provide further insights into beneficial effects of antioxidants in NASH prevention, we employed two manganese-supero...
متن کاملPrevention of nonalcoholic steatohepatitis in rats by two manganese-salen complexes.
BACKGROUND Nonalcoholic steatohepatitis (NASH), a progressive stage of nonalcoholic fatty liver disease (NAFLD), is characterized by steatosis with inflammation. Investigations have suggested that oxidative stress may play an important role in the progress of NAFLD to NASH. To provide further insights into beneficial effects of antioxidants in NASH prevention, we employed two manganese-superoxi...
متن کاملNonalcoholic steatohepatitis.
Nonalcoholic fatty liver disease (NAFLD) is being increasingly recognized as a common liver disorder that represents the hepatic manifestation of the metabolic syndrome, a variably defined aggregate of disorders related to obesity, insulin resistance, type II diabetes, hypertension and hyperlipidemia. Nonalcoholic steatohepatitis (NASH) is the progressive form of liver injury that carries a ris...
متن کاملNecroptosis in Nonalcoholic Steatohepatitis
Figure 1. Necroptosis is activated in human nonalcoholic steatohepatitis (NASH) samples. Representative immunohistochemical staining for phospho-MLKL on livers from different controls (Ctl) and NASH patients. Note the specific granular cytoplasmatic staining. See Gautheron et al for the specifics of the NASH cohort as well as the technical and ethical aspects. Dear Editor: One fundamental step ...
متن کاملPioglitazone in nonalcoholic steatohepatitis.
*KURAに登録されているコンテンツの利用については,著作権法に規定されている私的使用や引用などの範囲内で行ってください。 *著作権法に規定されている私的使用や引用などの範囲を超える利用を行う場合には,著作権者の許諾を得てください。ただし,著作権者 から著作権等管理事業者(学術著作権協会,日本著作出版権管理システムなど)に権利委託されているコンテンツの利用手続については ,各著作権等管理事業者に確認してください。 Title Pioglitazone in Nonalcoholic Steatohepatitis Author(s) Ota, Tsuguhito; Takamura, Toshinari; Kaneko, Shuichi Citation New England Journal of Medicine, 356(10): 1067-1069 Issue Date 20...
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عنوان ژورنال:
iranian biomedical journalجلد ۱۸، شماره ۱، صفحات ۴۱-۴۸
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